- Loss of the interest or pleasure in all or almost all activities.
- Lack of reactivity to usually pleasurable stimuli (does not feel much better even temporarily, when something good happens).
- Depression regularly worse in the morning.
- Early morning awaking (at least two hours before usually time).
- Psychomotor retardation or agitation (not merely subjective complaints).
- Significant anorexia or weight lost (e.g., more than 5% of body weight in a month).
- No significant personally disturbance before fist major depressive episode.
- One or more previous major depressives episodes followed by a complete, or early complete recovery.
- Previous good response to specific and adequate somatic antidepressant therapy.
DSM-111-R Criteria for Melancholia